Reveal The Api Active Pharmaceutical Ingredient Of Chinese Medicine Have New Tactics
Chinese medicine and natural medicine chemical composition and biological activity of the study is to clarify the scientific connotation of traditional Chinese medicine treatment of disease, to achieve the premise of traditional Chinese medicine and the basis. The separation of api active pharmaceutical ingredient in natural medicine is a major problem in the study, such as large workload, poor targeting and high repetition rate, which makes it difficult to improve the separation efficiency of active components.
China University of Pharmaceutical Sciences Vice President Kong Lingyi led the team, after 20 years of efforts to create a series of chromatographic and spectral techniques for automatic separation of the preparation of separation and structural identification of integrated traditional Chinese medicine and natural medicine chemical composition separation of new technologies found that biologically active compounds and Novel compounds. The application of new technology to speed up the basic research and development of traditional Chinese medicine material, and promote the modernization of Chinese medicine and internationalization, by the National Science and Technology Progress in 2015 second prize.
Exploring New Techniques for Chemical Composition Separation of Traditional Chinese Medicine
Sample loss, low separation efficiency is the natural drug chemical composition of the stumbling block. In the 1980s, a high-speed countercurrent chromatography technique developed by American scholars, with its solid support, separates the material according to the difference in the distribution coefficient of the material in the two phases, avoiding the loss of samples caused by irreversible adsorption of traditional chromatographic techniques , Inactivation, denaturation, etc., not only the sample can be fully recovered, the recovery of the sample more reflect its original characteristics, especially for the separation of natural api active pharmaceutical ingredient.
(HSCCC, HPLC, MPLC) and spectroscopy (MS) were used to establish the chromatographic separation of various api active pharmaceutical ingredient in traditional Chinese medicine. The chromatographic separation (HSCCC, HPLC, MPLC) and spectroscopy (MS) were used to establish the chromatographic separation And the development of automatic separation of the spectrum of technology separation and structural identification of integrated traditional Chinese medicine and natural medicine chemical composition separation series of new technologies, significantly enhance the natural active compounds and structural compounds of the discovery and separation of novel levels.
This technology can promote the basic material of Chinese medicine to clarify, based on traditional Chinese medicine and natural drug api active pharmaceutical ingredient of new drugs found, traditional Chinese medicine quality control standards improve and improve the research work. The application of new technology to drug research and development and production practice can effectively improve the level of new drugs to solve the key technical problems for China's traditional Chinese medicine industry to provide a strong technical support.
Study on the Composition of Traditional Chinese Medicine Based on New Technology
Over the years, Kong Lingyi led the research group to apply new technology, from more than 60 kinds of traditional Chinese medicine and natural medicine isolated and identified more than 5,000 compounds, found more than 600 new compounds, of which 25 new skeleton compounds. At the same time, the establishment of traditional Chinese medicine and natural medicine compound library, in traditional Chinese medicine and natural medicine research and development play an important role.
In addition, the project carried out a systematic study on the biological activity of the compounds, clarified the material basis of the clinical treatment of some traditional Chinese medicine and medicinal plants, identified 42 compounds with hypoglycemic, anti-allergic asthma, anti-tumor and other significant activities, And laid the foundation for the development of new drugs with independent intellectual property rights, of which two compounds were listed as national science and technology major major new drugs to create candidate drugs.